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Nucleic Acids Res. 2020 Jan 8;48(D1):D296-D306. doi: 10.1093/nar/gkz1030.

ELM-the eukaryotic linear motif resource in 2020.

Author information

1
Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg 69117, Germany.
2
Collaboration for Joint PhD Degree between EMBL and Heidelberg University, Faculty of Biosciences.
3
Institute of Enzymology, Research Centre for Natural Sciences, Budapest 1117, Hungary.
4
Instituto de Investigaciones Biotecnológicas (IIBio) and Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de San Martín. Av. 25 de Mayo y Francia, CP1650, Buenos Aires, Argentina.
5
Nazarbayev University, Nur-Sultan 010000, Kazakhstan.
6
Department of Science and Technology, Universidad Nacional de Quilmes - CONICET, Bernal B1876BXD, Buenos Aires, Argentina.
7
The Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Rd, Chelsea, London SW3 6JB, UK.

Abstract

The eukaryotic linear motif (ELM) resource is a repository of manually curated experimentally validated short linear motifs (SLiMs). Since the initial release almost 20 years ago, ELM has become an indispensable resource for the molecular biology community for investigating functional regions in many proteins. In this update, we have added 21 novel motif classes, made major revisions to 12 motif classes and added >400 new instances mostly focused on DNA damage, the cytoskeleton, SH2-binding phosphotyrosine motifs and motif mimicry by pathogenic bacterial effector proteins. The current release of the ELM database contains 289 motif classes and 3523 individual protein motif instances manually curated from 3467 scientific publications. ELM is available at: http://elm.eu.org.

PMID:
31680160
DOI:
10.1093/nar/gkz1030

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