Format

Send to

Choose Destination
Neuroimage. 2019 Oct 31:116321. doi: 10.1016/j.neuroimage.2019.116321. [Epub ahead of print]

The topographical organization of motor processing: An ALE meta-analysis on six action domains and the relevance of Broca's region.

Author information

1
Max Planck Institute for Human Cognitive and Brain Sciences, Department of Neuropsychology, Stephanstraße 1a, 04103, Leipzig, Germany; International Max Planck Research School on Neuroscience of Communication: Function, Structure, and Plasticity, Stephanstraße 1a, 04103, Leipzig, Germany. Electronic address: papitto@cbs.mpg.de.
2
Max Planck Institute for Human Cognitive and Brain Sciences, Department of Neuropsychology, Stephanstraße 1a, 04103, Leipzig, Germany.

Abstract

Action is a cover term used to refer to a large set of motor processes differing in domain specificities (e.g. execution or observation). Here we review neuroimaging evidence on action processing (N = 416; Subjects = 5912) using quantitative Activation Likelihood Estimation (ALE) and Meta-Analytic Connectivity Modeling (MACM) approaches to delineate the functional specificities of six domains: (1) Action Execution, (2) Action Imitation, (3) Motor Imagery, (4) Action Observation, (5) Motor Learning, (6) Motor Preparation. Our results show distinct functional patterns for the different domains with convergence in posterior BA44 (pBA44) for execution, imitation and imagery processing. The functional connectivity network seeding in the motor-based localized cluster of pBA44 differs from the connectivity network seeding in the (language-related) anterior BA44. The two networks implement distinct cognitive functions. We propose that the motor-related network encompassing pBA44 is recruited when processing movements requiring a mental representation of the action itself.

KEYWORDS:

Action domains; Activation likelihood estimation; Broca’s area; Meta-analysis; Meta-analytic connectivity modeling

Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center