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J Allergy Clin Immunol. 2019 Oct 31. pii: S0091-6749(19)31414-9. doi: 10.1016/j.jaci.2019.10.021. [Epub ahead of print]

Conflicting verdicts on peanut OIT from the ICER and FDA Advisory Committee; where do we go from here?

Author information

1
Division of Immunology and Allergy, Food Allergy and Anaphylaxis Program, The Department of Pediatrics, The Hospital for Sick Children, Toronto, Canada; Research Institute, The Hospital for Sick Children, Translational Medicine, Toronto, Canada; Department of Immunology, The University of Toronto, Toronto, Canada.
2
Texas Children's Hospital, Department of Pediatrics, Section of Immunology, Allergy and Retrovirology, Houston, TX, USA; Baylor College of Medicine, Houston, TX, USA.
3
Department of Pediatric Medicine, Pediatric Allergology Unit, Bambino Gesù Children's research Hospital (IRCCS), Rome, Italy.
4
Division of Immunology and Allergy, Department of Pediatrics, CHU Ste-Justine, Montreal, Canada; Division of Immunology and Allergy, Department of Medicine, Centre Hospitalier de l'Université de Montréal, Montreal, Canada.
5
Division of Pediatric Allergy and Clinical Immunology, Department of Pediatrics, McGill University Health Center, Montreal, QC, Canada.
6
Department of Pediatric Pneumology, Immunology and Intensive Care, Charité Universitätsmedizin Berlin, Berlin, Germany.
7
Dept. of Children and Adolescent Medicine, Division of Pneumology, Allergology and Cystic fibrosis, University Hospital Frankfurt, Frankfurt am Main, Germany.
8
Department of Women and Children's Health (Pediatric Allergy), School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK; Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King's College London, London, UK; Children's Allergy Service, Evelina London, Guy's and St Thomas' Hospital, London, UK.
9
Division of Pediatric Allergy, Department of Pediatrics, University Hospitals of Geneva, Geneva, Switzerland.
10
Division of Allergy and Immunology, Department of Pediatrics, University of British Columbia, BC Children's Hospital, Vancouver, British Columbia, Canada.
11
Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford University, Stanford, CA, USA; Division of Pulmonary and Critical Care Medicine, Stanford University, Stanford, CA, USA.
12
Division of Immunology and Allergy, Department of Pediatrics, CHU Ste-Justine, Montreal, Canada.
13
The Institute of Allergy, Immunology and Pediatric Pulmonology, Yitzhak Shamir Medical Center and Department of Pediatrics, Sackler Faculty of Medicine, Tel Aviv University, Israel.
14
Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford University, Stanford, CA, USA; Department of Pathology and Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA.
15
Department of Paediatric Allergy and Pulmonology, Oslo University Hospital, Oslo, Norway.
16
Department of Pathophysiology and Allergy Research, Medical University of Vienna, Austria.
17
Division of Clinical Immunology and Allergy, Department of Medicine, Western University, London, Canada; Division of Clinical Immunology and Allergy, Department of Medicine, McMaster University, Hamilton, Canada.
18
Department of Pediatrics, National Jewish Health, Denver, and the Department of Pediatrics, University of Colorado at Denver Health Sciences Center, Aurora, Colorado, USA.
19
Food Allergy Centre -Veneto Region, Department of Woman and Child Health , Padua University Hospital, Padua, Italy.
20
Division of Population Medicine, School of Medicine, The National Centre for Population Health and Wellbeing Research, Wales, UK.
21
Department of Pediatrics, Allergy Unit, University of Messina, Messina, Italy.
22
Division of Immunology and Allergy, Food Allergy and Anaphylaxis Program, The Department of Pediatrics, The Hospital for Sick Children, Toronto, Canada.
23
Division of Allergy and Immunology, Department of Dermatology, Allergy and Venerology, Charité Universitätsmedizin Berlin, Germany.
24
Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford University, Stanford, CA, USA; Division of Pulmonary and Critical Care Medicine, Stanford University, Stanford, CA, USA; Division of Allergy, Immunology and Rheumatology, Stanford University, Stanford, CA, USA. Electronic address: knadeau@stanford.edu.

KEYWORDS:

FDA Allergenic Products Advisory Committee; Institute for Clinical and Economic Review; Quality of Life; efficacy; food allergy; management; peanut allergy; safety; treatment

PMID:
31678426
DOI:
10.1016/j.jaci.2019.10.021

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