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Nat Commun. 2019 Nov 1;10(1):4996. doi: 10.1038/s41467-019-12847-6.

The receptor-like kinase NIK1 targets FLS2/BAK1 immune complex and inversely modulates antiviral and antibacterial immunity.

Author information

1
State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei, 430070, China. boli@mail.hzau.edu.cn.
2
The Provincial Key Lab of Plant Pathology of Hubei Province, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, 430070, China. boli@mail.hzau.edu.cn.
3
National Institute of Science and Technology in Plant-Pest Interactions, Bioagro, Viçosa, MG, 36570.900, Brazil.
4
Department of Biochemistry and Molecular Biology, Universidade Federal de Viçosa, Viçosa, MG, 36570.900, Brazil.
5
State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei, 430070, China.
6
The Provincial Key Lab of Plant Pathology of Hubei Province, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, 430070, China.
7
Federal Institute of Education from Goias, Science and Technology, Urutaí, GO, 75790-000, Brazil.
8
Department of Plant Pathology and Microbiology, Institute for Plant Genomics and Biotechnology, Texas A&M University, College Station, TX, 77843, USA.
9
Instituto Federal de Educação, Ciência e Tecnologia Catarinense, Rio do Sul, SC, 89163-356, Brazil.
10
Laboratório Nacional de Computação Cientifica (LNCC), Petrópolis, RJ, Brazil.
11
Department of Biochemistry and Biophysics, Institute for Plant Genomics and Biotechnology, Texas A&M University, College Station, TX, 77843, USA.
12
National Institute of Science and Technology in Plant-Pest Interactions, Bioagro, Viçosa, MG, 36570.900, Brazil. bbfontes@ufv.br.
13
Department of Biochemistry and Molecular Biology, Universidade Federal de Viçosa, Viçosa, MG, 36570.900, Brazil. bbfontes@ufv.br.

Abstract

Plants deploy various immune receptors to recognize pathogens and defend themselves. Crosstalk may happen among receptor-mediated signal transduction pathways in the same host during simultaneous infection of different pathogens. However, the related function of the receptor-like kinases (RLKs) in thwarting different pathogens remains elusive. Here, we report that NIK1, which positively regulates plant antiviral immunity, acts as an important negative regulator of antibacterial immunity. nik1 plants exhibit dwarfed morphology, enhanced disease resistance to bacteria and increased PAMP-triggered immunity (PTI) responses, which are restored by NIK1 reintroduction. Additionally, NIK1 negatively regulates the formation of the FLS2/BAK1 complex. The interaction between NIK1 and FLS2/BAK1 is enhanced upon flg22 perception, revealing a novel PTI regulatory mechanism by an RLK. Furthermore, flg22 perception induces NIK1 and RPL10A phosphorylation in vivo, activating antiviral signalling. The NIK1-mediated inverse modulation of antiviral and antibacterial immunity may allow bacteria and viruses to activate host immune responses against each other.

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