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Clin Respir J. 2019 Nov 1. doi: 10.1111/crj.13101. [Epub ahead of print]

Ultrasound mapping of lung changes in idiopathic pulmonary fibrosis.

Author information

1
Department of Radiology, University of Medicine and Pharmacy "Victor Babes", Timisoara, Romania.
2
Department of Pulmonology, University of Medicine and Pharmacy "Victor Babes", Timisoara, Romania.
3
Department of Biostatistics and Medical Informatics, University of Medicine and Pharmacy "Victor Babes", Timisoara, Romania.

Abstract

INTRODUCTION:

Idiopathic pulmonary fibrosis (IPF) is the most common and severe form of idiopathic interstitial pneumonias, accounted for 20% of cases of interstitial lung disease (ILD). In this study, we sought to compare the lung changes of IPF using a lung ultrasound (LUS) protocol of 12 zones with "current standard" high resolution computed tomography (HRCT) diagnostic method and overlap it with the functional pulmonary test as a complete clinical and imaging evaluation.

METHODS:

31 patients were included in the study and performed HRCT and pulmonary functional tests (PFT). A 12-lung zones LUS protocol was used and compared with HRCT and PFT.

RESULTS:

HRCT total fibrotic score had a correlation coefficient of 0.454 (p <0.005) with predicted FVC and 0.713 with predicted DLCO (p <0.001). Both the median of the number of B-lines and the average of the thickness of the pleural line obtained in the LUS assessment had a positively and statistically significant correlation with the HRCT fibrotic score p<0.001. The pleural thickness of 2.4 mm is the cut-off value of the mild form of fibrosis with a sensitivity of 0.958 and a specificity of 0.994.

CONCLUSION:

B-lines and the average thickness of the pleural line as LUS markers of the fibrotic interstitial syndrome are highly and positively correlated with HRCT score, FVC, and DLCO. LUS as a complementary method in the clinical management of IPF could be used more often by skilled clinicians to assess patients in terms of possible diagnosis and monitoring of IPF.

KEYWORDS:

diagnostic imaging; idiopathic pulmonary fibrosis; multi-detector computed tomography; ultrasonography

PMID:
31675455
DOI:
10.1111/crj.13101

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