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Clin Respir J. 2019 Nov 1. doi: 10.1111/crj.13101. [Epub ahead of print]

Ultrasound mapping of lung changes in idiopathic pulmonary fibrosis.

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Department of Radiology, University of Medicine and Pharmacy "Victor Babes", Timisoara, Romania.
Department of Pulmonology, University of Medicine and Pharmacy "Victor Babes", Timisoara, Romania.
Department of Biostatistics and Medical Informatics, University of Medicine and Pharmacy "Victor Babes", Timisoara, Romania.



Idiopathic pulmonary fibrosis (IPF) is the most common and severe form of idiopathic interstitial pneumonias, accounted for 20% of cases of interstitial lung disease (ILD). In this study, we sought to compare the lung changes of IPF using a lung ultrasound (LUS) protocol of 12 zones with "current standard" high resolution computed tomography (HRCT) diagnostic method and overlap it with the functional pulmonary test as a complete clinical and imaging evaluation.


31 patients were included in the study and performed HRCT and pulmonary functional tests (PFT). A 12-lung zones LUS protocol was used and compared with HRCT and PFT.


HRCT total fibrotic score had a correlation coefficient of 0.454 (p <0.005) with predicted FVC and 0.713 with predicted DLCO (p <0.001). Both the median of the number of B-lines and the average of the thickness of the pleural line obtained in the LUS assessment had a positively and statistically significant correlation with the HRCT fibrotic score p<0.001. The pleural thickness of 2.4 mm is the cut-off value of the mild form of fibrosis with a sensitivity of 0.958 and a specificity of 0.994.


B-lines and the average thickness of the pleural line as LUS markers of the fibrotic interstitial syndrome are highly and positively correlated with HRCT score, FVC, and DLCO. LUS as a complementary method in the clinical management of IPF could be used more often by skilled clinicians to assess patients in terms of possible diagnosis and monitoring of IPF.


diagnostic imaging; idiopathic pulmonary fibrosis; multi-detector computed tomography; ultrasonography


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