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HLA. 2019 Nov 1. doi: 10.1111/tan.13741. [Epub ahead of print]

HLA antibodies in haematopoietic stem cell transplantation.

Author information

1
Histocompatibility and Immunogenetics Laboratory, Gartnavel General Hospital, 21 Shelley Road, Glasgow, G12 0ZD.
2
Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, G12 8QQ.

Abstract

The negative impact of donor specific HLA alloantibodies in solid organ transplantation is well known and understood within the Histocompatibility and Immunogenetics community. However the influence of DSA in the outcome of haematopoietic stem cell transplantation is less well regarded. As donor choices have evolved from HLA matched siblings and extremely well matched unrelated donors to mismatched cord blood and haplo-identical related donors, we are now identifying more patients with antibodies reactive against their donor mismatches. The clinical significance of the antibodies that can be detected has not yet been fully elucidated. This article is protected by copyright. All rights reserved.

KEYWORDS:

HLA; antibody; stem-cell; transplant

PMID:
31674146
DOI:
10.1111/tan.13741

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