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Science. 2019 Nov 1;366(6465). pii: eaan4673. doi: 10.1126/science.aan4673.

Clonal hematopoiesis in human aging and disease.

Author information

1
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA. sjaiswal@stanford.edu benjamin_ebert@dfci.harvard.edu.
2
Department of Medical Oncology, Howard Hughes Medical Institute, Boston, MA. sjaiswal@stanford.edu benjamin_ebert@dfci.harvard.edu.
3
Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

Abstract

As people age, their tissues accumulate an increasing number of somatic mutations. Although most of these mutations are of little or no functional consequence, a mutation may arise that confers a fitness advantage on a cell. When this process happens in the hematopoietic system, a substantial proportion of circulating blood cells may derive from a single mutated stem cell. This outgrowth, called "clonal hematopoiesis," is highly prevalent in the elderly population. Here we discuss recent advances in our knowledge of clonal hematopoiesis, its relationship to malignancies, its link to nonmalignant diseases of aging, and its potential impact on immune function. Clonal hematopoiesis provides a glimpse into the process of mutation and selection that likely occurs in all somatic tissues.

PMID:
31672865
DOI:
10.1126/science.aan4673

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