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Biol Psychiatry. 1988 Sep;24(5):515-21.

Limbic pathology in schizophrenia: the entorhinal region--a morphometric study.

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  • 1C. u. O. Vogt-Institute of Brain Research, University of Düsseldorf, F.R.G.


The volume of the entorhinal region is significantly reduced in postmortem brains of schizophrenics compared with controls (p less than 0.017). In addition, a significant reduction of neurons (p less than 0.017), but no significant increase in absolute glial cell numbers, is found. These results are consistent with the hypothesis that structural changes in the medial temporal lobe of schizophrenics may be developmental in origin.

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