Send to

Choose Destination
Ther Apher Dial. 2019 Oct 31. doi: 10.1111/1744-9987.13450. [Epub ahead of print]

Quality of life and emotional distress in peritoneal dialysis and hemodialysis patients.

Author information

Department of Nephrology, Aichi Welfare Cooperative Agricultural Federation Konan-Kosei Hospital, 137 Omatsubara, Takaya-cho, Konan City, Aichi, 483-8704, Japan.



Cardiovascular disease-associated morbidity and mortality are reportedly higher in hemodialysis (HD) patients compared with peritoneal dialysis (PD) patients. However, few studies have estimated changes in state of depression and cognitive impairment in patients undergoing HD and PD. The present study evaluated the impact of HD or PD on patients' quality of life (QoL), cognitive impairment, and depression status over two years.


This 24-month observational, prospective study included 45 HD and 30 PD patients. Patients were assessed before and every 12 months after starting dialysis for 24 months. Measurements included QoL [36-Item Short-Form Health Survey (SF-36)], cognitive impairment [Mini-Mental State Examination (MMSE)], depressive state [Center for Epidemiologic Studies Depression Scale (CES-D)], grip strength, and 24-h urine volume (UV).


Physical and social component scores of the SF-36 significantly improved in PD patients at 24 months compared with those observed at baseline (42.8 vs. 39.4; P < 0.05 and 46.4 vs. 37.3; P < 0.05, respectively); however, scores remained unchanged in HD patients. MMSE scores were significantly decreased at 12 and 24 months in HD patients (29.0 vs. 26.0, 25.0; P < 0.05), but remained unchanged in PD patients. Moreover, CES-D scores significantly worsened at 24 months in HD patients (12.8 vs. 16.5), but remained unchanged in PD. Preservation of UV and grip strength was associated with SF-36, CES-D, and MMSE scores.


Our findings indicate that PD is associated with higher QoL and recovery from cognitive failure compared with HD. This article is protected by copyright. All rights reserved.


Peritoneal dialysis; cognitive impairment; emotional distress; hemodialysis; quality of life


Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center