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An Pediatr (Barc). 2020 Feb;92(2):65-70. doi: 10.1016/j.anpedi.2019.08.005. Epub 2019 Oct 24.

[Basal renal function in paediatric patients: correlation of methods that depend on a 24h urine collection with simpler methods that do not require a timed urine].

[Article in Spanish]

Author information

1
Sección de Nefrología Pediátrica, Hospital Universitario Donostia, San Sebastián, España. Electronic address: m.mercedes.ubetagoyenaarrieta@osakidetza.net.
2
Sección de Nefrología Pediátrica, Hospital Universitario Donostia, San Sebastián, España.

Abstract

INTRODUCTION:

In daily clinical practice a quick, easy and accessible method is needed to adequately assess renal function. The objectives of this study were: 1. To quantify the relationship and concordance of the glomerular filtration rate (GF) calculated by the clearance of creatinine in 24h urine (CCr) and the original and modified Schwartz equation (SE); and 2. To correlate urine elimination of substances that depends on the volume of excreted urine in a unit of time with other parameters that are calculated measuring the concentration of these substances in blood and urine.

MATERIAL AND METHODS:

The study included 401 healthy children with ages between 3 to 14 years (187 male and 214 female). The analysis between the variables was carried out using Pearson's correlation coefficient and the intraclass correlation coefficient (ICC).

RESULTS:

The correlation between values of CCr and the original SE (non-standardised creatinine measurement) was r=0.58 (P<0.001) and the concordance, ICC=0.74. The correlation between CCr values and the modified SE (standardised creatinine measurement) was r=0.68 (P<.001), and the concordance ICC=0.78. There was a very significant correlation between the elimination of sodium in a 24h urine (mEq/kg/24h) and the Na-Fractional-Excretion (EFNa): r=0.8 (P<.001). There was a correlation between the potassium elimination in 24h (mEq/kg/24h) and EFK: r=0.85 (P<.001). Between volume/min/1.73m2 and the urine volume percent of GF was: r=0.88 (P<.001).

CONCLUSIONS:

These equations provide valuable information of the state of the basal renal function without having to use a timed urine.

KEYWORDS:

Glomerular filtration rate; Kidney function test; Niños; Paediatric; Potasio; Potassium; Pruebas de función renal; Sodio; Sodium; Tasa de filtración glomerular

PMID:
31668896
DOI:
10.1016/j.anpedi.2019.08.005
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