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Alzheimers Dement (Amst). 2019 Sep 25;11:659-669. doi: 10.1016/j.dadm.2019.08.006. eCollection 2019 Dec.

Correlation between cognitive impairment and retinal neural loss assessed by swept-source optical coherence tomography in patients with mild cognitive impairment.

Author information

1
Department of Neurology, Federal University of Juiz de Fora Medical School, Juiz de Fora, Minas Gerais, Brazil.
2
Department of Ophthalmology, Federal University of Juiz de Fora Medical School, Juiz de Fora, Minas Gerais, Brazil.
3
Juiz de Fora Eye Hospital, Juiz de Fora, Minas Gerais, Brazil.
4
Division of Ophthalmology, University of São Paulo Medical School, São Paulo, Brazil.

Abstract

Introduction:

We compared peripapillary retinal nerve fiber layer and macular thickness measurements in patients with mild cognitive impairment (MCI) and control subjects using swept-source optical coherence tomography (SS-OCT). We also assessed the relationship between SS-OCT measurements and the severity of cognitive impairment.

Methods:

Peripapillary retinal nerve fiber layer and macular thickness were measured in 23 patients and 24 control subjects using SS-OCT. Cognitive status was assessed using the Mini-Mental State Examination, the Montreal Cognitive Assessment, and the Pfeffer Questionnaire.

Results:

Most inner retinal layer thickness parameters were significantly smaller in patients with MCI, especially macular ganglion cell complex thickness measurements. Mini-Mental State Examination and Montreal Cognitive Assessment findings were significantly correlated with most macular thickness parameters.

Discussion:

The SS-OCT-measured inner retinal layers of patients with MCI displayed thinning, especially in the central macular area. SS-OCT technology can provide useful information on ocular involvement patterns and holds promise as an ocular biomarker in this patient population.

KEYWORDS:

Alzheimer's disease; Dementia; Ganglion cell layer; Macula; Mild cognitive impairment; Optic nerve; Optical coherence tomography; Retina; Retinal nerve fiber layer; Swept-source

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