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Clin Microbiol Rev. 2019 Oct 30;33(1). pii: e00009-19. doi: 10.1128/CMR.00009-19. Print 2019 Dec 18.

A Comprehensive Update on the Problem of Blood Culture Contamination and a Discussion of Methods for Addressing the Problem.

Author information

1
Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA gdoern@nc.rr.com.
2
Division of Medical Microbiology, Department of Pathology, John Hopkins University School of Medicine, Baltimore, Maryland, USA.
3
Division of Infectious Diseases, Department of Medicine and Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
4
Department of Pharmacy Practice and Translational Research, University of Houston College of Pharmacy, Houston, Texas, USA.
5
Division of Infectious Diseases, Department of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
6
Department of Pathology and Laboratory Medicine, Department of Medicine, Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
7
Division of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.

Abstract

SUMMARYIn this review, we present a comprehensive discussion of matters related to the problem of blood culture contamination. Issues addressed include the scope and magnitude of the problem, the bacteria most often recognized as contaminants, the impact of blood culture contamination on clinical microbiology laboratory function, the economic and clinical ramifications of contamination, and, perhaps most importantly, a systematic discussion of solutions to the problem. We conclude by providing a series of unanswered questions that pertain to this important issue.

KEYWORDS:

blood culture contamination

PMID:
31666280
PMCID:
PMC6822992
[Available on 2020-10-30]
DOI:
10.1128/CMR.00009-19

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