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J Infect Dis. 2019 Oct 30. pii: jiz391. doi: 10.1093/infdis/jiz391. [Epub ahead of print]

An Intranasal Exposure Model of Lethal Nipah Virus Infection in African Green Monkeys.

Author information

1
Galveston National Laboratory, Galveston.
2
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston.

Abstract

Due to the difficulty in conducting clinical trials for vaccines and treatments against Nipah virus (NiV), licensure will likely require animal models, most importantly nonhuman primates (NHPs). The NHP models of infection have primarily relied on intratracheal instillation or small particle aerosolization of NiV. However, neither of these routes adequately models natural mucosal exposure to NiV. To develop a more natural NHP model, we challenged African green monkeys with the Bangladesh strain of NiV by the intranasal route using the LMA mucosal atomization device (MAD). More important, LMA MAD exposure resulted in uniformly lethal disease that accurately reflected the human condition.

KEYWORDS:

Nipah virus; animal model; henipavirus; pathogenesis; primate

PMID:
31665362
DOI:
10.1093/infdis/jiz391

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