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J Infect Dis. 2019 Oct 30. pii: jiz469. doi: 10.1093/infdis/jiz469. [Epub ahead of print]

A Lethal Aerosol Exposure Model of Nipah Virus Strain Bangladesh in African Green Monkeys.

Author information

1
Galveston National Laboratory, Galveston, Texas, USA.
2
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.

Abstract

The high case-fatality rates and potential for use as a biological weapon make Nipah virus (NiV) a significant public health concern. Previous studies assessing the pathogenic potential of NiV delivered by the aerosol route in African green monkeys (AGMs) used the Malaysia strain (NiVM), which has exhibited lower instances of respiratory illness and person-to-person transmission during human outbreaks than the Bangladesh strain (NiVB). Accordingly, we developed a small particle aerosol model of NiVB infection in AGMs. Consistent with other mucosal AGM models of NiVB infection, we achieved uniform lethality and disease pathogenesis reflective of that observed in humans.

KEYWORDS:

aerosol; Nipah virus; animal model; pathogenesis; primate

PMID:
31665351
DOI:
10.1093/infdis/jiz469

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