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Hepatol Res. 2019 Oct 29. doi: 10.1111/hepr.13442. [Epub ahead of print]

Liver stiffness does not affect ultrasound-guided attenuation coefficient measurement in the evaluation of hepatic steatosis.

Author information

1
Department of Gastroenterology and Hepatology, Ogaki Municipal Hospital, Ogaki, Gifu, Japan.
2
Department of Diagnostic Radiology, Ogaki Municipal Hospital, Ogaki, Gifu, Japan.
3
Department of Imaging Diagnosis, Ogaki Municipal Hospital, Ogaki, Gifu, Japan.
4
Ultrasound General Imaging, GE Healthcare, Hino, Tokyo, Japan.
5
Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan.
6
Department of Epidemiology, Infectious Disease Control, and Prevention, Hiroshima University Institute of Biomedical and Health Sciences, Hiroshima, Japan.

Abstract

AIMS:

Recently, a new method has been developed to diagnose hepatic steatosis with attenuation coefficients based on the ultrasound-guided attenuation parameter (UGAP). We investigated whether fibrosis identified by hepatic stiffness measurements based on magnetic resonance elastography (MRE) affects attenuation coefficient measurement using UGAP for the evaluation of hepatic steatosis.

METHODS:

A total of 608 patients with chronic liver disease were analyzed. Correlations between magnetic resonance imaging-determined proton density fat fraction (PDFF) or MRE value and attenuation coefficients were evaluated. In addition, the interaction between hepatic fibrosis and attenuation coefficient was analyzed.

RESULTS:

The correlation coefficient (r) between PDFF values and attenuation coefficient values was 0.724, indicating a strong relationship. Conversely, the r between MRE values and attenuation coefficient values was -0.187, indicating almost no relationship. In the multiple regression assessment of the effect of PDFF and MRE on attenuation coefficient based on UGAP, the p values for PDFF, MRE, and PDFF×MRE were <0.001, 0.277, and 0.903, respectively. In patients with non-alcoholic fatty liver disease (n=169), the r between PDFF values and attenuation coefficient values was 0.695, indicating a moderate relationship. Conversely, the r between MRE values and attenuation coefficient values was -0.068, indicating almost no relationship. In the multiple regression assessment of the effect of PDFF and MRE on attenuation coefficient based on UGAP, the p values for PDFF, MRE, and PDFF×MRE were <0.001, 0.948, and 0.706, respectively.

CONCLUSION:

UGAP-determined attenuation coefficient was weakly affected by liver stiffness, an indicator of hepatic fibrosis.

KEYWORDS:

attenuation coefficient; hepatic steatosis; interaction; liver stiffness; ultrasound

PMID:
31661724
DOI:
10.1111/hepr.13442

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