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Br J Dermatol. 1988 Jul;119(1):79-82.

Effect of isotretinoin on eccrine gland function.

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Department of Dermatology, Royal Victoria Infirmary, Newcastle-upon-Tyne, U.K.


Sweat secretion rate, stimulated by iontophoresis of pilocarpine, was measured before and during treatment with isotretinoin in 20 patients. Sweat secretion was increased during treatment in 15 patients (75%), but the mean increase of 15% was not statistically significant (P = 0.085, paired t-test; 95% confidence limits-0.2% to +30%) and no patients had a clinically apparent alteration of sweating. We conclude that there is no important change in stimulated sweating associated with isotretinoin therapy.

[Indexed for MEDLINE]

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