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Anticancer Agents Med Chem. 2019 Oct 18. doi: 10.2174/1871520619666191018172926. [Epub ahead of print]

New Entrants into Clinical Trials for Targeted Therapy of Breast Cancer: An Insight.

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Molecular Biology Research Lab, Department of Zoology, Deshbandhu College, University of Delhi, Kalkaji, New Delhi, 110019. India.
Department of Botany, Hansraj College, University of Delhi, New Delhi, 110007. India.


Breast cancer is too complex with various different molecular alterations involved in its pathogenesis and progression. Over the decade, we have seen a surge in the development of drugs for bimolecular targets and for the signal transduction pathways involving, in treatment line of breast cancer. These drugs, either alone or in combination with conventional treatments like chemotherapy, hormone therapy and radiotherapy, will help oncologists to get better insight and do the needful treatment. But, these novel therapies bring various challenges along with them, which include the dosage selection, patient selection, schedule of treatment and weighing of clinical benefits over side effects. In this review, we highlight the recently studied target molecules that have received indications in breast carcinoma, both in the localized and in advanced state and about their inhibitors which are in clinical development which can give immense potential to clinical care in the near future.


Breast cancer; CDK4/6; EGFR; androgen receptor; aromatase; drug design; drug targets; inhibitors; notch

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