Send to

Choose Destination
Mol Cells. 2019 Oct 31;42(10):687-692. doi: 10.14348/molcells.2019.0214.

Transfer RNA-Derived Small Non-Coding RNA: Dual Regulator of Protein Synthesis.

Author information

Department of Life Sciences, Chung-Ang University, Seoul 06974, Korea.


Transfer RNA-derived small RNAs (tsRNAs) play a role in various cellular processes. Accumulating evidence has revealed that tsRNAs are deeply implicated in human diseases, such as various cancers and neurological disorders, suggesting that tsRNAs should be investigated to develop novel therapeutic intervention. tsRNAs provide more complexity to the physiological role of transfer RNAs by repressing or activating protein synthesis with distinct mechanisms. Here, we highlight the detailed mechanism of tsRNA-mediated dual regulation in protein synthesis and discuss the necessity of novel sequencing technology to learn more about tsRNAs.


tRF; tRNA; translation; tsRNA

Supplemental Content

Full text links

Icon for Publishing M2Community Icon for PubMed Central
Loading ...
Support Center