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J Addict Med. 2019 Oct 22. doi: 10.1097/ADM.0000000000000574. [Epub ahead of print]

Pharmacological and Psychosocial Treatment of Adults with Gambling Disorder: A Meta-Review.

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Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy (MDN, FDC, CR, LM, MM, LD, AL, SM, GG, FM, MLC, SDP, LJ); Dipartimento di Epidemiologia, Regione Lazio, ASL Roma 1, Rome, Italy (FDC, GLD, LA); Pediatric University Hospital-Department (DPUO), Bambino Gesù Children's Hospital, Rome, Italy (FDC); Department of Psychiatry, University of Oxford, Oxford, UK (FDC); School of Hygiene and Preventive Medicine, University of Rome Tor Vergata, Rome, Italy (GLD); Mental Health Department, ASL Roma 1, Rome, Italy (IP).



Gambling disorder (GD) leads to impaired socioeconomical functioning and increased social costs. Although the research on GD has been rising over the years, approved treatment guidelines are currently not available. The aim of this study was to systematically review the literature on the pharmacological and psychosocial treatment of adults with GD, and to identify possible agreed-upon standards of care.


MEDLINE, PubMed, Cochrane, Web of Science, Embase, and CINAHL electronic databases were searched up to April 2019 for systematic reviews on pharmacological, psychosocial, and combined treatment of adults with GD. Twenty-six studies were eventually included in this meta-review.


Studies reported promising results of opioid antagonists and mood stabilizers in reducing GD-related symptomatology. Lithium was particularly effective in subjects with comorbid bipolar disorders. Cognitive behavioral therapy (CBT) was the most commonly used psychological intervention and reduced global severity, gambling frequency, and financial loss. Motivational interviewing (MI) seemed to improve several GD domains, alone or in combination with CBT. Self-help interventions (SHIs) showed some efficacy in promoting treatment-seeking, and in combination with other treatments.


We found moderate evidence of effect for CBT, but weaker evidence for pharmacotherapy and SHIs. Results suggested some efficacy for MI in the short but not in the long term. It is likely that certain interventions might be more effective than others on specific features of GD. Further studies are needed to compare the efficacy and acceptability of individual and combined psychosocial and pharmacological interventions, to deliver patient-tailored treatments.

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