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Alzheimers Dement (N Y). 2019 Oct 14;5:610-617. doi: 10.1016/j.trci.2019.09.006. eCollection 2019.

Vascular retinal biomarkers improves the detection of the likely cerebral amyloid status from hyperspectral retinal images.

Author information

Genie Electrique, Polytechnique Montreal, Montreal, Quebec, Canada.
Optina Diagnostics, Montreal, Quebec, Canada.
Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Département de médecine nucléaire, Hôpital Maisonneuve-Rosemont, Montreal, Quebec, Canada.
Translational Neuroimaging Laboratory, McGill Centre for Studies in Aging, Douglas Mental Health University Institute, Montreal, Quebec, Canada.
Clinique ophtalmologique 2121, Montreal, Quebec, Canada.
Département de psychiatrie, Hôpital Maisonneuve-Rosemont, Montreal, Quebec, Canada.
Translational Neuroimaging Laboratory, McGill Centre for Studies in Aging Douglas Mental Health University Institute, Montreal, Quebec, Canada.
MoCA Clinic and Institute, Greenfield Park, Quebec, Canada.
Alzheimer's Disease Research Unit, The McGill University Research Centre for Studies in Aging, Montreal, Quebec, Canada.
Research Center, Montreal Heart Institute, Montreal, Quebec, Canada.



This study investigates the relationship between retinal image features and β-amyloid (Aβ) burden in the brain with the aim of developing a noninvasive method to predict the deposition of Aβ in the brain of patients with Alzheimer's disease.


Retinal images from 20 cognitively impaired and 26 cognitively unimpaired cases were acquired (3 images per subject) using a hyperspectral retinal camera. The cerebral amyloid status was determined from binary reads by a panel of 3 expert raters on 18F-florbetaben positron-emission tomography (PET) studies. Image features from the hyperspectral retinal images were calculated, including vessels tortuosity and diameter and spatial-spectral texture measures in different retinal anatomical regions.


Retinal venules of amyloid-positive subjects (Aβ+) showed a higher mean tortuosity compared with the amyloid-negative (Aβ-) subjects. Arteriolar diameter of Aβ+ subjects was found to be higher than the Aβ- subjects in a zone adjacent to the optical nerve head. Furthermore, a significant difference between texture measures built over retinal arterioles and their adjacent regions were observed in Aβ+ subjects when compared with the Aβ-. A classifier was trained to automatically discriminate subjects combining the extracted features. The classifier could discern Aβ+ subjects from Aβ- subjects with an accuracy of 85%.


Significant differences in texture measures were observed in the spectral range 450 to 550 nm which is known as the spectral region known to be affected by scattering from amyloid aggregates in the retina. This study suggests that the inclusion of metrics related to the retinal vasculature and tissue-related textures extracted from vessels and surrounding regions could improve the discrimination performance of the cerebral amyloid status.


Alzheimer; Beta amyloid; Image processing; Machine learning; Multispectral fundus imaging; Retina

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