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Front Cell Dev Biol. 2019 Oct 10;7:206. doi: 10.3389/fcell.2019.00206. eCollection 2019.

Selective Phosphorylation of Akt/Protein-Kinase B Isoforms in Response to Dietary Cues.

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TU Dresden (BIOTEC), Dresden, Germany.
Paul Langerhans Institute Dresden of the Helmholtz Zentrum München at the University Hospital and Faculty of Medicine Carl Gustav Carus of TU Dresden, Technische Universität Dresden, Dresden, Germany.
German Center for Diabetes Research (DZD e.V.), Oberschleissheim, Germany.


A calorie-rich diet is one reason for the continuous spread of metabolic syndromes in western societies. Smart food design is one powerful tool to prevent metabolic stress, and the search for suitable bioactive additives is a continuous task. The nutrient-sensing insulin pathway is an evolutionary conserved mechanism that plays an important role in metabolism, growth and development. Recently, lipid cues capable to stimulate insulin signaling were identified. However, the mechanistic base of their activity remains obscure to date. We show that specific Akt/Protein-kinase B isoforms are responsive to different calorie-rich diets, and potentiate the activity of the cellular insulin cascade. Our data add a new dimension to existing models and position Drosophila as a powerful tool to study the relation between dietary lipid cues and the insulin-induced cellular signal pathway.


Akt; Akt phosphorylation; Cystobasidium oligophagum; Drosophila; PKB; Saccharomyces cerevisiae; insulin signaling; yeast lipids

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