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Trends Cell Biol. 2019 Dec;29(12):964-973. doi: 10.1016/j.tcb.2019.09.002. Epub 2019 Oct 21.

Cell Fusion: Merging Membranes and Making Muscle.

Author information

1
Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
2
Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA. Electronic address: douglas.millay@cchmc.org.

Abstract

Cell fusion is essential for the development of multicellular organisms, and plays a key role in the formation of various cell types and tissues. Recent findings have highlighted the varied protein machinery that drives plasma-membrane merger in different systems, which is characterized by diverse structural and functional elements. We highlight the discovery and activities of several key sets of fusion proteins that together offer an evolving perspective on cell membrane fusion. We also emphasize recent discoveries in vertebrate myoblast fusion in skeletal muscle, which is composed of numerous multinucleated myofibers formed by the fusion of progenitor cells during development.

KEYWORDS:

cell fusion; fusogens; myoblast fusion; myomaker; myomerger; skeletal muscle

PMID:
31648852
DOI:
10.1016/j.tcb.2019.09.002

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