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Physiol Rep. 2019 Oct;7(20):e14257. doi: 10.14814/phy2.14257.

Blue light at night acutely impairs glucose tolerance and increases sugar intake in the diurnal rodent Arvicanthis ansorgei in a sex-dependent manner.

Author information

1
Institute of Cellular and Integrative Neurosciences (INCI), UPR-3212 CNRS, University of Strasbourg, Strasbourg, France.
2
Hypothalamic Integration Mechanisms, Netherlands Institute for Neuroscience (NIN), Amsterdam, The Netherlands.
3
Department of Endocrinology and Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Abstract

In our modern society, the exposure to light at night (LAN) has increased considerably, which may impact human health negatively. Especially exposure to light at night containing short wavelength emissions (~450-500 nm) can disrupt the normal function of the biological clock, altering sleep-wake cycles and inducing metabolic changes. Recently, we reported that light at night acutely impairs glucose tolerance in nocturnal rats. However, light at night in nocturnal rodents coincides with their activity period, in contrast to artificial light at night exposure in humans. The aim of this study was to evaluate the acute effects of blue (λ = 490 ± 20 nm) artificial light at night (bALAN) on glucose metabolism and food intake in both male and female diurnal Sudanian grass rats (Arvicanthis ansorgei) fed either regular chow or a free choice high-fat high sucrose diet (HFHS). In both chow and HFHS fed male Arvicanthis, 1-hour of bALAN exposure induced a higher glucose response in the oral glucose tolerance test (OGTT) accompanied by a significant decrease in plasma insulin. Furthermore, in HFHS fed animals, bALAN induced an increase in sucrose intake during the dark phase in males but not in females. Additionally, 1-h of bALAN increased the nonfasted glucose levels together with plasma corticosterone in female grass rats. These results provide new and further evidence for the deleterious effects of exposure to short wavelength emission-containing artificial light at night on glucose metabolism in a diurnal rodent in a sex-dependent manner.

KEYWORDS:

Arvicanthis ansorgei ; Blue light; circadian clock; food intake; glucose intolerance; high-fat high-sugar diet; insulin sensitivity

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