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Comb Chem High Throughput Screen. 2019 Oct 22. doi: 10.2174/1386207322666191022130235. [Epub ahead of print]

Green synthesis of 4H-pyran derivatives using Fe3O4-MNPs as efficient nanocatalyst: Study of antioxidant activity.

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Department of chemistry, East Tehran Branch, Islamic Azad University, Tehran. Iran.
Department of Chemistry, Qaemshahr Branch, Islamic Azad University, Qaemshahr. Iran.


Aims & Objective: In this work, pyran derivatives was synthesized via multicomponent reaction of ninhydrine, α-haloketones, dialkyl acetylenedicarboxylate and triphenylphosphine in the presence of iron oxide magnetic nanoparticles (Fe3O4-MNPs) as efficient nanocatalyst in ethanol at room temperature.


The biosynthesis of Fe3O4-MNPs was performed by Clover Leaf water extract. In addition, antioxidant activity was examined for the some prepared compounds employing DPPH radical scavenging and ferric reduction activity potential (FRAP) experiment and comparing results with synthetic antioxidants (TBHQ and BHT).


Compound 5b was shown excellent radical trapping activity and good reducing activity relative to standards (BHT and TBHQ).


Some advantages of this procedure are: the workup of reaction is easy and the products can be separated easily by filtration. Fe3O4-MNPs display a good improvement in the yield of the product and showed significant reusable activity.


Diels-Alder reactions; Fe3O4-MNPs; Ninhydrine; Pyran; green synthesis; α;-haloketones

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