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Nutr Metab Cardiovasc Dis. 2019 Dec;29(12):1408-1417. doi: 10.1016/j.numecd.2019.08.003. Epub 2019 Aug 14.

The probiotic Lactobacillus fermentum 296 attenuates cardiometabolic disorders in high fat diet-treated rats.

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Department of Nutrition, Health Sciences Center, Federal University of Paraíba, João Pessoa, Brazil.
Department of Food Engineering, Technology Center, Federal University of Paraiba, Joao Pessoa, Brazil.
Biotechnology Center, Federal University of Paraíba, João Pessoa, Brazil.
Department of Nutrition, Health Sciences Center, Federal University of Paraíba, João Pessoa, Brazil. Electronic address:



High-fat (HF) diet consumption has been associated with gut dysbiosis and increased risk of dyslipidemia, type 2 diabetes mellitus and hypertension. Probiotic administration has been suggested as a safe therapeutic strategy for the treatment of cardiometabolic disorders. This study was designed to assess the effects of probiotic Lactobacillus (L.) fermentum 296, a fruit-derived bacteria strain, against cardiometabolic disorders induced by HF diet.


Male Wistar rats were divided into control diet (CTL); HF diet; and HF diet treated with Lactobacillus fermentum 296 (HF + Lf 296). The L. fermentum 296 strain at 1 × 109 colony forming units (CFU)/ml were daily administered by oral gavage for 4 weeks. The results showed that rats fed with HF diet displayed insulin resistance, reduced Lactobacillus spp. counts in feces, serum lipids, and oxidative profile. Rats fed on HF diet also demonstrated augmented blood pressure associated with sympathetic hyperactivity and impaired baroreflex control. The administration of L. fermentum 296 for 4 weeks recovered fecal Lactobacillus sp. counts and alleviated hyperlipidemia, sympathetic hyperactivity, and reduced systolic blood pressure in HF rats without affecting baroreflex sensibility.


Our results suggest the ability of L. fermentum 296 improve biochemical and cardiovascular parameters altered in cardiometabolic disorders.


Dyslipidemia; Hypertension; Lactobacillus fermentum; Microbiota; Probiotics

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