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BMC Infect Dis. 2019 Oct 22;19(1):870. doi: 10.1186/s12879-019-4555-5.

Clinical outcomes among hospital patients with Middle East respiratory syndrome coronavirus (MERS-CoV) infection.

Author information

1
College of Medicine, Sulaiman Al Rajhi Colleges, P.O. Box 777, Bukayriah, Al-Qassim, Zip code 51941, Saudi Arabia.
2
Buraidah Central Hospital, Buraidah, Saudi Arabia.
3
College of Medicine, Sulaiman Al Rajhi Colleges, P.O. Box 777, Bukayriah, Al-Qassim, Zip code 51941, Saudi Arabia. a.saquib@sr.edu.sa.

Abstract

BACKGROUND:

Mortality is high among patients with Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection. We aimed to determine hospital mortality and the factors associated with it in a cohort of MERS-CoV patients.

METHODS:

We reviewed hospital records of confirmed cases (detection of virus by polymerase chain reaction from respiratory tract samples) of MERS-CoV patients (n = 63) admitted to Buraidah Central Hospital in Al-Qassim, Saudi Arabia between 2014 and 2017. We abstracted data on demography, vital signs, associated conditions presented on admission, pre-existing chronic diseases, treatment, and vital status. Bi-variate comparisons and multiple logistic regressions were the choice of data analyses.

RESULTS:

The mean age was 60 years (SD = 18.2); most patients were male (74.6%) and Saudi citizens (81%). All but two patients were treated with Ribavirin plus Interferon. Hospital mortality was 25.4%. Patients who were admitted with septic shock and/or organ failure were significantly more likely to die than patients who were admitted with pneumonia and/or acute respiratory distress syndrome (OR = 47.9, 95% CI = 3.9, 585.5, p-value 0.002). Age, sex, and presence of chronic conditions were not significantly associated with mortality.

CONCLUSION:

Hospital mortality was 25%; septic shock/organ failure at admittance was a significant predictor of mortality.

KEYWORDS:

Interferon alpha; MERS-CoV; Mortality; Ribavirin

PMID:
31640578
PMCID:
PMC6805532
DOI:
10.1186/s12879-019-4555-5
[Indexed for MEDLINE]
Free PMC Article

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