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Int J Mol Sci. 2019 Oct 21;20(20). pii: E5220. doi: 10.3390/ijms20205220.

Roles of Thyroid Hormone-Associated microRNAs Affecting Oxidative Stress in Human Hepatocellular Carcinoma.

Huang PS1,2, Wang CS3, Yeh CT4, Lin KH5,6,7,8.

Author information

1
Department of Biochemistry, College of Medicine, Chang-Gung University, Taoyuan 33302, Taiwan. leo_6813@msn.com.
2
Department of Biomedical Sciences, College of Medicine, Chang-Gung University, Taoyuan 33302, Taiwan. leo_6813@msn.com.
3
Department of General Surgery, Chang Gung Memorial Hospital, Chiayi 61363, Taiwan. wangcs@cgmh.org.tw.
4
Liver Research Center, Chang Gung Memorial Hospital, Linkou, Taoyuan 33302, Taiwan. chauting@adm.cgmh.org.tw.
5
Department of Biochemistry, College of Medicine, Chang-Gung University, Taoyuan 33302, Taiwan. khlin@mail.cgu.edu.tw.
6
Department of Biomedical Sciences, College of Medicine, Chang-Gung University, Taoyuan 33302, Taiwan. khlin@mail.cgu.edu.tw.
7
Liver Research Center, Chang Gung Memorial Hospital, Linkou, Taoyuan 33302, Taiwan. khlin@mail.cgu.edu.tw.
8
Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 33302, Taiwan. khlin@mail.cgu.edu.tw.

Abstract

Oxidative stress occurs as a result of imbalance between the generation of reactive oxygen species (ROS) and antioxidant genes in cells, causing damage to lipids, proteins, and DNA. Accumulating damage of cellular components can trigger various diseases, including metabolic syndrome and cancer. Over the past few years, the physiological significance of microRNAs (miRNA) in cancer has been a focus of comprehensive research. In view of the extensive level of miRNA interference in biological processes, the roles of miRNAs in oxidative stress and their relevance in physiological processes have recently become a subject of interest. In-depth research is underway to specifically address the direct or indirect relationships of oxidative stress-induced miRNAs in liver cancer and the potential involvement of the thyroid hormone in these processes. While studies on thyroid hormone in liver cancer are abundantly documented, no conclusive information on the potential relationships among thyroid hormone, specific miRNAs, and oxidative stress in liver cancer is available. In this review, we discuss the effects of thyroid hormone on oxidative stress-related miRNAs that potentially have a positive or negative impact on liver cancer. Additionally, supporting evidence from clinical and animal experiments is provided.

KEYWORDS:

liver cancer; microRNA; oxidative stress; thyroid hormone

PMID:
31640265
PMCID:
PMC6834183
DOI:
10.3390/ijms20205220
[Indexed for MEDLINE]
Free PMC Article

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