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Curr Biol. 2019 Oct 21;29(20):R1086-R1088. doi: 10.1016/j.cub.2019.08.069.

Xenophagy: Pathogen-Containing Vacuoles Are Hard to Digest.

Author information

1
Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA.
2
Department of Microbiology, University of Washington, Seattle, WA 98195, USA; Department of Medicine, University of Washington, Seattle, WA 98195, USA; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA. Electronic address: millersi@uw.edu.

Abstract

Many intracellular pathogens reside in host-membrane-encased vacuoles, but the mechanism initiating xenophagic targeting of these vacuoles was unknown. A recent study identifies the host vacuolar-ATPase as essential to xenophagic clearance and the Salmonellae effector SopF that inhibits bacterial clearance by its ADP-ribosylation.

PMID:
31639355
DOI:
10.1016/j.cub.2019.08.069

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