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Future Oncol. 2019 Nov;15(33):3763-3774. doi: 10.2217/fon-2019-0443. Epub 2019 Oct 22.

Comparison of accelerometer-derived physical activity levels between individuals with and without cancer: a UK Biobank study.

Author information

1
Centre for Observational Research & Data Sciences, Bristol-Myers Squibb, Uxbridge, UB8 1DH, UK.
2
Data Analytics, Evidera, The Ark, 201 Talgarth Rd, London W6 8BJ, UK.
3
UK Medical, Bristol-Myers Squibb, Uxbridge, UB8 1DH, UK.
4
Worldwide Health Economics & Outcomes Research, Bristol-Myers Squibb, Uxbridge, UB8 1DH, UK.

Abstract

Aim: To identify the difference in physical activity (PA) levels between individuals with and without cancer, and to estimate all-cause mortality associated with this difference. Methods: Current cancer, cancer survivor and cancer-free groups were identified from the UK Biobank. We used multivariate and Cox regression to estimate PA differences and association of PA with all-cause mortality. Results: Compared with the cancer-free individuals, participants in the two cancer groups had fewer minutes in moderate-to-vigorous PA per day in adjusted analyses. The PA difference was associated with higher mortality in the current cancer group. Conclusion: Patients with a history of cancer were less active than those without cancer, and PA is associated with increased mortality. PA improvement strategies in cancer patients must be explored.

KEYWORDS:

UK Biobank; accelerometer; all-cause mortality; cancer; physical activity

PMID:
31637942
DOI:
10.2217/fon-2019-0443
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