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Nat Ecol Evol. 2019 Oct 21. doi: 10.1038/s41559-019-0997-9. [Epub ahead of print]

Interspecific hybridization facilitates niche adaptation in beer yeast.

Author information

1
VIB-KU Leuven Center for Microbiology, Leuven, Belgium.
2
CMPG Laboratory of Genetics and Genomics, Department M2S, KU Leuven, Leuven, Belgium.
3
Leuven Institute for Beer Research, Leuven, Belgium.
4
Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.
5
VIB Center for Plant Systems Biology, Ghent, Belgium.
6
White Labs Inc., San Diego, CA, USA.
7
Research Center Weihenstephan for Brewing and Food Quality, TU München, Freising, Germany.
8
ABInBev SA/NV, Leuven, Belgium.
9
Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium.
10
Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium. steven.maere@ugent.vib.be.
11
VIB Center for Plant Systems Biology, Ghent, Belgium. steven.maere@ugent.vib.be.
12
VIB-KU Leuven Center for Microbiology, Leuven, Belgium. kevin.verstrepen@kuleuven.vib.be.
13
CMPG Laboratory of Genetics and Genomics, Department M2S, KU Leuven, Leuven, Belgium. kevin.verstrepen@kuleuven.vib.be.
14
Leuven Institute for Beer Research, Leuven, Belgium. kevin.verstrepen@kuleuven.vib.be.

Abstract

Hybridization between species often leads to non-viable or infertile offspring, yet examples of evolutionarily successful interspecific hybrids have been reported in all kingdoms of life. However, many questions on the ecological circumstances and evolutionary aftermath of interspecific hybridization remain unanswered. In this study, we sequenced and phenotyped a large set of interspecific yeast hybrids isolated from brewing environments to uncover the influence of interspecific hybridization in yeast adaptation and domestication. Our analyses demonstrate that several hybrids between Saccharomyces species originated and diversified in industrial environments by combining key traits of each parental species. Furthermore, posthybridization evolution within each hybrid lineage reflects subspecialization and adaptation to specific beer styles, a process that was accompanied by extensive chimerization between subgenomes. Our results reveal how interspecific hybridization provides an important evolutionary route that allows swift adaptation to novel environments.

PMID:
31636425
DOI:
10.1038/s41559-019-0997-9

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