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J Perinatol. 2019 Oct 21. doi: 10.1038/s41372-019-0534-3. [Epub ahead of print]

Outcomes of neonates with listeriosis supported with extracorporeal membrane oxygenation from 1991 to 2017.

Author information

1
Department of Pediatrics, Section of Neonatal-Perinatal Medicine, Yale School of Medicine, New Haven, CT, USA.
2
Department of Surgery, Division of Pediatric Surgery, Yale School of Medicine, New Haven, CT, USA.
3
Department of Pathology, Yale School of Medicine, New Haven, CT, USA.
4
Department of Surgery, Division of Pediatric Surgery, Yale School of Medicine, New Haven, CT, USA. robert.cowles@yale.edu.

Abstract

BACKGROUND:

Listeriosis may cause severe disease in fetuses and neonates. The outcomes of critically ill neonates with early-onset listeriosis requiring extracorporeal membrane oxygenation (ECMO) from 1975 to 1991 have been reported.

OBJECTIVE:

To update the characteristics and outcomes of neonates with listeriosis supported by ECMO.

STUDY DESIGN:

Retrospective study of neonates with culture-proven listeriosis reported to the Extracorporeal Life Support Organization Registry between 1991 and 2017. Comparisons were made between this cohort and the case series from 1975-1991.

RESULTS:

Twenty-two neonates had culture-proven Listeria monocytogenes infection and required ECMO support. Eight-six percent survived to discharge, compared with 67% in the previous cohort (p = 0.2). The median ECMO duration was 131 h, compared with 209 h in the previous cohort (p = 0.1). Nonsurvivors had a significantly lower pre-ECMO pH (6.91 vs 7.31, p = 0.0006).

CONCLUSION:

The survival of neonates with listeriosis supported with ECMO is high, supporting the use of ECMO as rescue therapy for this condition.

PMID:
31636340
DOI:
10.1038/s41372-019-0534-3

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