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Sci Data. 2019 Oct 21;6(1):214. doi: 10.1038/s41597-019-0213-4.

The FluPRINT dataset, a multidimensional analysis of the influenza vaccine imprint on the immune system.

Author information

1
Institute of Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, 94304, USA. info@adrianatomic.com.
2
Oxford Vaccine Group, Department of Pediatrics, University of Oxford, Oxford, OX3 9DU, UK. info@adrianatomic.com.
3
Independent Researcher, Stanford, USA.
4
Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, 94304, USA.
5
Human Immune Monitoring Center, Stanford University, Stanford, CA, 94304, USA.
6
Institute of Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, 94304, USA. mmdavis@stanford.edu.
7
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, 94304, USA. mmdavis@stanford.edu.
8
Howard Hughes Medical Institute, Stanford University, Stanford, CA, 94304, USA. mmdavis@stanford.edu.

Abstract

Machine learning has the potential to identify novel biological factors underlying successful antibody responses to influenza vaccines. The first attempts have revealed a high level of complexity in establishing influenza immunity, and many different cellular and molecular components are involved. Of note is that the previously identified correlates of protection fail to account for the majority of individual responses across different age groups and influenza seasons. Challenges remain from the small sample sizes in most studies and from often limited data sets, such as transcriptomic data. Here we report the creation of a unified database, FluPRINT, to enable large-scale studies exploring the cellular and molecular underpinnings of successful antibody responses to influenza vaccines. Over 3,000 parameters were considered, including serological responses to influenza strains, serum cytokines, cell phenotypes, and cytokine stimulations. FluPRINT, facilitates the application of machine learning algorithms for data mining. The data are publicly available and represent a resource to uncover new markers and mechanisms that are important for influenza vaccine immunogenicity.

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