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Br J Dermatol. 2019 Oct 20. doi: 10.1111/bjd.18618. [Epub ahead of print]

Age-and gender-appropriate cancer screening risks missing most occult malignancies in young dermatomyositis patients.

Author information

1
Penn State Hershey College of Medicine, 500 University Drive, Hershey, PA, USA.
2
Penn State Hershey Medical Center, Department of Dermatology, 500 University Drive, Hershey, PA, USA.
3
Penn State Hershey Medical Center, Section of Rheumatology, 500 University Drive, Hershey, PA, USA.

Abstract

Dermatomyositis (DM) is an autoimmune disease associated with malignancy. Reported incidence of cancer ranges from 7-30% in adult DM patients, with most studies clustered around 15-20% (1). The risk is elevated above the baseline population 3 years prior and 5 years following DM diagnosis. The period of greatest risk occurs in the first 3 years following diagnosis. Age >50 consistently shows strong association with the development of cancer. A retrospective analysis found most cancers were identified using blind screening, rather than symptom-guided or age-appropriate screenings.

PMID:
31630395
DOI:
10.1111/bjd.18618

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