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Clin Gastroenterol Hepatol. 2019 Oct 17. pii: S1542-3565(19)31165-6. doi: 10.1016/j.cgh.2019.10.021. [Epub ahead of print]

Cost-effectiveness of Active Identification and Subsequent Colonoscopy Surveillance of Lynch Syndrome Cases.

Author information

1
Department of Public Health, Erasmus University Medical Center, Rotterdam, the Netherlands. Electronic address: e.peterse@erasmusmc.nl.
2
Department of Public Health, Erasmus University Medical Center, Rotterdam, the Netherlands.
3
Strategy Division, Canadian Partnership Against Cancer, Toronto, Canada.
4
Pathology & Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada; Laboratory Medicine & Pathobiology, University of Toronto, Canada.
5
Sunnybrook Research Institute, Toronto, Canada.
6
Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, the Netherlands.
7
Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Canada.
8
Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Canada; Department of Surgery, Mount Sinai Hospital, Toronto, Canada.
9
Prevention and Cancer Control, Cancer Care Ontario and Department of Medicine, University of Toronto, Toronto, Canada.
10
Department of Surgery, LiKaShing Knowledge Institute St. Michael's Hospital, Toronto, Canada.

Abstract

BACKGROUND & AIMS:

The province of Ontario, Canada, is considering immunohistochemical followed by cascade analyses of all patients who received a diagnosis of colorectal cancer (CRC) at an age younger than 70 years to identify individuals with Lynch syndrome. We evaluated the costs and benefits of testing for Lynch syndrome and determined the optimal surveillance interval for first-degree relatives (FDRs) found to have Lynch syndrome.

METHODS:

We developed a patient flow diagram to determine costs and yield of immunohistochemical testing for Lynch syndrome in CRC cases and, for those found to have Lynch syndrome, their FDRs, accounting for realistic uptake. Subsequently, we used the MISCAN-colon model to compare costs and benefits of annual, biennial, and triennial surveillance in FDRs identified with Lynch syndrome vs colonoscopy screening every 10 years (usual care for individuals without a diagnosis of Lynch syndrome).

RESULTS:

Testing 1000 CRC cases was estimated to identify 20 CRC index cases and 29 FDRs with Lynch syndrome at a cost of $310,274. Despite the high cost of Lynch syndrome tests, offering the FDRs with Lynch syndrome biennial colonoscopy surveillance was cost effective at $8785 per life-year gained compared with usual care, due to a substantial increase in life-years gained (+122%) and cost savings in CRC care. Triennial surveillance was more costly and less effective, and annual surveillance showed limited additional benefit compared with biennial surveillance.

CONCLUSIONS:

Immunohistochemical testing for Lynch syndrome in persons younger than 70 years who received a diagnosis of colorectal cancer, and then testing first-degree relatives of those found to have Lynch syndrome, provides a good balance between costs and long-term benefits. Colonoscopy surveillance every 2 years is the optimal surveillance interval for patients with Lynch syndrome.

KEYWORDS:

colon; family; polyp; risk

PMID:
31629885
DOI:
10.1016/j.cgh.2019.10.021

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