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J Cell Biol. 2019 Nov 4;218(11):3535-3536. doi: 10.1083/jcb.201910040. Epub 2019 Oct 18.

Beware of thy neighbor: Senescent cancer cells feast on adjacent cells to persist.

Author information

1
Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL elsa.flores@moffitt.org marco.napoli@moffitt.org.
2
Cancer Biology and Evolution Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.

Abstract

Chemotherapy-resistant tumor cells are responsible for poor patient outcome. In this issue, Tonnessen-Murray et al. (2019. J. Cell Biol https://doi.org/10.1083/jcb.201904051) elegantly show that chemotherapy triggers macrophage-like features in surviving cancer cells, which in turn phagocyte normal and tumor cells alike to outlast dormancy and cause relapse.

PMID:
31628158
PMCID:
PMC6829664
[Available on 2020-05-04]
DOI:
10.1083/jcb.201910040

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