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Diabetes Care. 2020 Jan;43(1):247-249. doi: 10.2337/dc19-0365. Epub 2019 Oct 18.

Cannabis Use Is Associated With Increased Risk for Diabetic Ketoacidosis in Adults With Type 1 Diabetes: Findings From the T1D Exchange Clinic Registry.

Author information

1
Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO greg.kinney@ucdenver.edu.
2
Barbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO.
3
Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO.
4
Jaeb Center for Health Research, Tampa, FL.

Abstract

OBJECTIVE:

We examined the frequency of diabetic ketoacidosis (DKA) in cannabis users compared with nonusers in the T1D Exchange clinic registry (T1DX).

RESEARCH DESIGN AND METHODS:

The association between cannabis use by total substance score for cannabis (TSC) and DKA in the past 12 months was examined using a logistic regression model adjusted for potential confounders among adults in the T1DX.

RESULTS:

Of 932 adults with type 1 diabetes, 61 had a TSC >4, which classified them as moderate cannabis users. Adjusting for sex, age at study visit, and HbA1c, cannabis use was associated with a twofold increase in risk for DKA among adults with type 1 diabetes (odds ratio 2.5 [95% CI 1.0-5.9]).

CONCLUSIONS:

Cannabis use was associated with an increased risk for DKA among adults in the T1DX. Providers should inform their patients of the potential risk of DKA with cannabis use.

PMID:
31628116
DOI:
10.2337/dc19-0365

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