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J Mol Biol. 2019 Oct 15. pii: S0022-2836(19)30591-1. doi: 10.1016/j.jmb.2019.09.025. [Epub ahead of print]

Structural basis for the recognition of non-methylated DNA by the CXXC domain.

Author information

1
Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan 430079, PR China. Electronic address: keliu2015@mail.ccnu.edu.cn.
2
Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan 430079, PR China; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada; Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada. Electronic address: jr.min@utoronto.ca.

Abstract

CXXC domain-containing proteins are often involved in different biological processes, such as cell proliferation and development, apoptosis, DNA repair, signaling transduction and tumourigenesis, by regulating transcription. 12 CXXC domain-containing proteins have been identified in human, and structural together with DNA binding studies reveal that these CXXC domains, a 50-70 residues module of two conserved CXXCXXC motifs, bind to non-methylated DNA in different sequence contexts. These CXXC domain-containing proteins and their complexes regulate various biological processes and the CXXC domain plays an important role in the recruitment and regulation of their associated chromatin modifying activities. In this review, we summarize these human CXXC domain-containing proteins in terms of their structures, biology and biochemistry, and also discuss how they mediate crosstalk among different epigenetic modifications.

KEYWORDS:

CXXC domain; CXXC domain-containing protein; DNA binding; crosstalk; epigenetic modifications

PMID:
31626811
DOI:
10.1016/j.jmb.2019.09.025

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