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Medicine (Baltimore). 2019 Oct;98(42):e17568. doi: 10.1097/MD.0000000000017568.

Incidence of hydrocephalus in traumatic brain injury: A nationwide population-based cohort study.

Author information

1
Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Chiayi.
2
School of Medicine, Chang Gung University, Taoyuan.
3
Health Information and Epidemiology Laboratory.
4
Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Chiayi.
5
School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan.
6
Department of Pediatric Neurology, Chang Gung Memorial Hospital, Chiayi.
7
Department of Psychiatry, Wan-Fang Hospital and School of Medicine, College of Medicine, Taipei Medical University, Taipei.
8
Department of Psychiatry, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan.

Abstract

BACKGROUND:

The aim of this study was to investigate the risk and peak time of post-traumatic hydrocephalus (PTH) in traumatic brain injury (TBI) patients with traumatic subarachnoid hemorrhage (SAH), compared to TBI patients without traumatic SAH.

METHODS:

In this retrospective population-based cohort study, the data was extracted from Longitudinal Health Insurance Database from 2000 to 2010 in Taiwan. A total of 23,775 TBI patients who had a first event TBI during 2000 to 2010 were included and divided into TBI with SAH (TBI-S) group and TBI without SAH (TBI-NS) group. We focused on analyzing the PTH in both groups within 2 years after brain injury. Competing risk regression models were performed to assess the risk of developing PTH in the TBI-S group compared to the TBI-NS group.

RESULTS:

Comparing to the TBI-NS group, there was a significantly higher cumulative incidence of PTH in the TBI-S group during the 2-year follow-up period. The adjusted hazard ratio (HR) of PTH in TBI-S group within 2 years was between 2.90-3.47, and the highest estimates were obtained within 6 months after injury (HR = 3.47, 95% CI: 2.43-4.94). The occurrence percentage of PTH was highest during 0-3rd month follow-up periods (1.95% in TBI-S group; 0.48% in TBI-NS group).

CONCLUSIONS:

The peak time of PTH occurrence was noted during 0-3rd month post brain injury. Traumatic SAH patients had an approximate 3-fold risk of developing PTH, comparing to TBI patients without traumatic SAH.

PMID:
31626123
PMCID:
PMC6824727
DOI:
10.1097/MD.0000000000017568
[Indexed for MEDLINE]
Free PMC Article

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