Format

Send to

Choose Destination
Proc Natl Acad Sci U S A. 1988 Apr;85(7):2106-9.

Some retinoblastomas, osteosarcomas, and soft tissue sarcomas may share a common etiology.

Author information

1
University of Chicago, Department of Radiation and Cellular Oncology, IL 60637.

Abstract

DNA and RNA were extracted from primary human osteosarcomas and soft tissue sarcomas obtained from patients without retinoblastoma and were analyzed by hybridization with a cDNA probe for RB mRNA; absence or alterations of the RB gene are associated with development of retinoblastoma. Most of the osteosarcomas or soft tissue sarcomas examined by us did not express detectable levels of RB mRNA, whereas normal cells and epithelial tumor cells did. One osteosarcoma expressed a 2.4-kilobase transcript in addition to a normal 4.7-kilobase species. Our data suggest that transcriptional inactivation or post-transcriptional down-regulation of the RB gene may be important in the etiology of some osteosarcomas and soft tissue sarcomas as well as retinoblastomas.

PMID:
3162593
PMCID:
PMC279937
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center