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Med Sci (Paris). 2019 Oct;35(10):771-778. doi: 10.1051/medsci/2019155. Epub 2019 Oct 18.

[Pluripotent stem cells for the treatment of heart failure: current status, persisting issues and perspectives].

[Article in French; Abstract available in French from the publisher]

Author information

Université de Paris, PARCC, Inserm, F-75015 Paris, France.
Université de Paris, PARCC, Inserm, F-75015 Paris, France - Département de chirurgie cardio-vasculaire, Hôpital Européen Georges Pompidou, 20 rue Leblanc, 75015 Paris, France.


in English, French

Although the first wave of cell therapy trials has not commonly yielded clinically meaningful improvements, some encouraging hints have emerged which suggest that stem cells or their secreted products could ultimately find a place within the armamentarium of therapies that can be offered to patients with heart failure. In this setting, pluripotent stem cells raise a particular interest because of their unique ability to generate lineage-specific cells which can be transplanted at the desired stage of differentiation. This review discusses the current status of research in this field, the persisting roadblocks that need to be overcome and the approaches which might hasten the clinical applications of this cell type.


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