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Med Sci (Paris). 2019 Oct;35(10):753-760. doi: 10.1051/medsci/2019153. Epub 2019 Oct 18.

[Synthetic chromosomes: rewriting the code of life].

[Article in French; Abstract available in French from the publisher]

Author information

INRA, UMR 1332 de biologie du fruit et pathologie, 71 avenue E. Bourlaux, 33140 Villenave d'Ornon, France - Univ. Bordeaux, UMR 1332 de biologie du fruit et pathologie, 71 avenue E. Bourlaux 33140 Villenave d'Ornon, France.
Institute of veterinary bacteriology of Bern, Vetsuisse Faculty, University of Bern, 3001 Berne, Suisse.
Département de biologie, Université de Sherbrooke, 2500 boulevard de l'Université, J1K 2R1 Sherbrooke, Québec, Canada.


in English, French

The past decade has seen vast improvements in DNA synthesis and assembly methods. The creation of synthetic DNA molecules is becoming easier and more affordable, such that entire chromosomes can now be synthesized. These advances mark the beginning of synthetic genomics, a new discipline interested in the construction of complete genomes tailored for the study and application of biological systems. From viral genome synthesis to the reconstruction of the yeast 16 chromosomes, we discuss the main discoveries, the regulations and ethical considerations along with the potential of this emerging discipline for the future.


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