Format

Send to

Choose Destination
Behav Cogn Psychother. 2019 Oct 18:1-6. doi: 10.1017/S1352465819000584. [Epub ahead of print]

Rumination-focused cognitive behaviour therapy for non-responsive chronic depression: an uncontrolled group study.

Author information

1
Mental Health Centre North Zealand, Psychiatric Research Unit, Mental Health Centre North Zealand, Dyrehavevej 48, DK-3400 Hilleroed, Denmark.
2
Stolpegaard Psychotherapeutic Centre, Mental Health Services, Capital RegionDenmark.
3
Psychiatric Research Unit, Region Zealand Psychiatry, Denmark.
4
Department of Psychology, University of Copenhagen, Ă˜ster Farimagsgade 2A, DK-1353 Copenhagen K, Denmark.
5
SMART Lab, University of Exeter, Exeter EX4 4QG, UK.

Abstract

BACKGROUND:

One-third of patients with depression do not respond satisfactorily to treatment, and approximately 20% of all patients treated for depression develop a chronic depression. One approach to more effective treatment of chronic and treatment-resistant depression is to target rumination - an underlying mechanism implicated in the development and maintenance of depression.

AIM:

The purpose of this uncontrolled group study was to investigate the feasibility of individual rumination-focused cognitive behavioural therapy (RfCBT) for patients with chronic and treatment-resistant depression.

METHOD:

A total of 10 patients with chronic and treatment-resistant depression were offered 12-16 individual sessions of RfCBT. The primary outcome was depressive symptoms as measured by Hamilton Depression Scale at pre-, post- and 3-month follow-up. Secondary symptoms measured included self-reported rumination and worry.

RESULTS:

There was a significant reduction in depressive symptoms (p < 0.05), rumination (p < 0.01) and worry (p < 0.5) from pre- to post-treatment. Half of the participants (n = 5) showed significant reliable change on levels of depressive symptoms post-treatment. The reduction in depressive symptoms, rumination and worry were maintained at follow-up.

CONCLUSIONS:

RfCBT was associated with significant reductions in depressive symptoms in a small sample with chronic and treatment-resistant depression. Despite limitations of being a small uncontrolled study with limited follow-up, these results are promising in a difficult to treat population. RfCBT warrants further systematic evaluation.

KEYWORDS:

chronic treatment-resistant depression; rumination; rumination-focused cognitive behaviour therapy; uncontrolled group study; worry

PMID:
31625500
DOI:
10.1017/S1352465819000584

Supplemental Content

Full text links

Icon for Cambridge University Press
Loading ...
Support Center