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AJNR Am J Neuroradiol. 2019 Dec;40(12):2161-2165. doi: 10.3174/ajnr.A6282. Epub 2019 Oct 17.

White Matter Injury and Structural Anomalies in Infants with Prenatal Opioid Exposure.

Author information

1
From the Perinatal Institute, Division of Neonatology (S.L.M., N.A.P., B.B.P.) Stephanie.merhar@cchmc.org.
2
Department of Pediatrics (S.L.M., N.A.P., B.B.P.), University of Cincinnati College of Medicine, Cincinnati, Ohio.
3
From the Perinatal Institute, Division of Neonatology (S.L.M., N.A.P., B.B.P.).
4
Pediatric Neuroimaging Research Consortium (A.B.).
5
Department of Radiology (J.T., B.K.-F.), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Abstract

Previous studies have not found structural injury or brain malformations in infants and children with prenatal opioid exposure. As part of an ongoing study evaluating neuroimaging in infants with prenatal opioid exposure, we reviewed structural brain MR imaging in 20 term infants with prenatal opioid exposure and 20 term controls at 4-8 weeks of age. We found that 8 of the 20 opioid-exposed infants had punctate white matter lesions or white matter signal abnormality on structural MR imaging, and 2 of the opioid-exposed infants had a septopreoptic fusion anomaly. No controls had white matter injury or structural malformations. Our findings underscore the importance of clinical neurodevelopmental follow-up and the need for more comprehensive imaging and long-term outcomes research following prenatal opioid exposure.

PMID:
31624119
PMCID:
PMC6911627
[Available on 2020-06-01]
DOI:
10.3174/ajnr.A6282

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