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Int J Vitam Nutr Res. 2019 Oct 18:1-6. doi: 10.1024/0300-9831/a000616. [Epub ahead of print]

Low Vitamin B12 level and Vitamin D level Adversely Affect on Cochlear Health in Women.

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Ministry of Health, Malatya Training and Research Hospital, ENT Clinic, Malatya, Turkey.
Ministry of Health, Malatya Training and Research Hospital, Neurology Clinic, Malatya, Turkey.


The aim of this study is to examine the association between low serum vitamin B12 levels and low serum vitamin D levels and cochlear health in women. A prospective case-control study was carried out in the Department of Otolaryngology, Malatya Training and Research Hospital between 2017-2018. Thirty (30) patients with vitamin B12 deficiency (a mean age of 32.5 ± 1.7 years(y) women); 30 patients with vitamin D deficiency (a mean age of 32.3 ± 1.58 y women) and 30 controls (a mean age of 27.8 ± 1.48 y women) were recruited. The study participants have no evidence of symptomatic hearing loss. Transiently evoked otoacoustic emissions (TEOAEs) and distortion product otoacoustic emissions (DPOAEs) of the study participants were recorded. A comparative analysis of the parameters revealed that results at TEOAE 1,2,3,4 kHz (p = 0.013, p = 0.002, p = 0.001, p = 0.001, respectively) and at DPOAE 1, 2, 6 kHz (p < 0.001, p < 0.001, p = 0.002, respectively) were somewhat lower in patients with vitamin B12 deficient group when compared with the controls. Moreover, TEOAE 3,4 kHz (p = 0.005, p = 0.013 respectively) and DPOAE 1,2,6 kHz (p = 0.005, p = 0.01, p = 0.031, respectively) were lower in the vitamin D deficiency group compared with the controls. There was a significant association between both vitamin B12 deficiency and vitamin D deficiency and cochlear health. Patients with vitamin B12 and vitamin D deficiency should be evaluated for cochlear function.


Cochlear health; otoacoustic emission; vitamin B12; vitamin D; women


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