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Curr Drug Metab. 2019 Oct 16. doi: 10.2174/1389200220666191016124958. [Epub ahead of print]

Superparamagnetic Iron Oxide Nanoparticles (SPIONs) for Diagnosis and Treatment of Breast, Ovarian and Cervical Cancers.

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Department of Biotechnology, Institute of Technology, GITAM (Deemed to be University), Visakhapatnam. India.
Cancer Biology Lab, Department of Biochemistry and Bioinformatics, Institute of Science, GITAM (Deemed to be University), Visakhapatnam. India.



The potential of Super Paramagnetic Iron Oxide Nanoparticles (SPIONs) as theranostic agents for cancer has been investigated extensively. SPIONS can be utilized for diagnostic imaging, drug delivery as well as for therapeutic applications. SPIONS are of particular interest because of their potential for non-invasive diagnosis and non-invasive therapeutic applications. This article is a review of in vivo and clinical studies of SPIONs for diagnosis and treatment of breast, ovarian and cervical cancer. The current limitations of this technology with relation to clinical therapeutic applications and the potential to overcome these limitations are also discussed.


NCBI Pubmed was searched for relevant documents by using keyword and MESH based search. The following keyword combinations were used: 'breast cancer' and SPION, 'ovarian cancer' and SPION, and 'cervical cancer' and SPION. The resulting list was manually scanned for studies involving clinical and in vivo studies.


The 29 most relevant publications were identified and reviewed.


Although numerous in vitro and in vivo studies have demonstrated the safety and effectiveness of the use of SPIONs for both diagnostic and therapeutic applications, there is relatively little progress towards translation to clinical applications involving breast, ovarian and cervical cancer.


MRI; SPION; breast cancer; cervical cancer; non-invasive imaging; ovarian cancer; theranostics

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