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Curr Mol Med. 2019 Oct 16. doi: 10.2174/1566524019666191016150757. [Epub ahead of print]

Curcumin activates the Nrf2 pathway and induces cellular protection against oxidative injury.

Author information

1
Department of Basic Science, Faculty of Veterinary Medicine Faculty, University of Tabriz, Tabriz. Iran.
2
Department of Basic Science, Veterinary Medicine Faculty, Shushtar University, Khuzestan. Iran.
3
Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman. Iran.
4
Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand. Iran.
5
Department of Basic Medical Science, Neyshabur University of Medical Sciences, Neyshabur. Iran.

Abstract

Curcumin is a naturally occurring polyphenol which is isolated from the rhizome of Curcuma longa (turmeric). This medicinal compound has different biological activities including antioxidant, antibacterial, antineoplastic, and anti-inflammation. It has also therapeutic effects for cancer, neurodegenerative disorders, renal disorders, and diabetes mellitus. Curcumin is safe and well-tolerated at high concentrations without making toxicity. In the present review, we demonstrated curcumin affects the Nrf2 signaling pathway to exert its therapeutic and biological activities.

KEYWORDS:

Nuclear factor erythroid 2-related factor 2; cancer; curcumin; therapeutic effect

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