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Curr Mol Med. 2019 Oct 16. doi: 10.2174/1566524019666191016150757. [Epub ahead of print]

Curcumin activates the Nrf2 pathway and induces cellular protection against oxidative injury.

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Department of Basic Science, Faculty of Veterinary Medicine Faculty, University of Tabriz, Tabriz. Iran.
Department of Basic Science, Veterinary Medicine Faculty, Shushtar University, Khuzestan. Iran.
Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman. Iran.
Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand. Iran.
Department of Basic Medical Science, Neyshabur University of Medical Sciences, Neyshabur. Iran.


Curcumin is a naturally occurring polyphenol which is isolated from the rhizome of Curcuma longa (turmeric). This medicinal compound has different biological activities including antioxidant, antibacterial, antineoplastic, and anti-inflammation. It has also therapeutic effects for cancer, neurodegenerative disorders, renal disorders, and diabetes mellitus. Curcumin is safe and well-tolerated at high concentrations without making toxicity. In the present review, we demonstrated curcumin affects the Nrf2 signaling pathway to exert its therapeutic and biological activities.


Nuclear factor erythroid 2-related factor 2; cancer; curcumin; therapeutic effect

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