Format

Send to

Choose Destination
J Infect Dis. 2019 Oct 17. pii: jiz527. doi: 10.1093/infdis/jiz527. [Epub ahead of print]

rs73185306 C/T is not a predisposing risk factor for inherited chromosomally-integrated human herpesvirus 6A/B.

Author information

1
Division of Infectious and Immune Diseases, CHU de Quebec Research Center-Université Laval, Quebec City, Canada.
2
Montreal Heart Institute, Montréal, Québec Canada.
3
Faculté de Médecine, Departement de Médecine, Université de Montréal, Montréal, Québec, Canada.
4
Department of Microbiology, infectious disease and immunology, Faculty of Medicine, Laval University.

Abstract

Approximately 1% of the world population carry a copy of the human herpesvirus 6A or 6B (HHV-6A/B) in every cell of their body. This condition is referred to as inherited chromosomally-integrated HHV-6A/B (iciHHV-6A/B). The mechanisms leading to iciHHV-6A/B chromosomal integration are yet to be identified. A recent report suggested that the rs73185306 C/T SNP represents a favorable predisposing factor leading to HHV-6A/B integration. After genotype analysis of an independent cohort (N=11,967), we report no association between rs73185306 C/T SNP and HHV-6A/B chromosomal integration (OR=0.90, 95% CI: 0.54-1.51; P=0.69).

KEYWORDS:

HHV-6; HHV-6A/B; Herpesviruses; iciHHV-6; integration; rs73185306 C/T SNP

PMID:
31621866
DOI:
10.1093/infdis/jiz527

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center