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Ann Card Anaesth. 2019 Oct-Dec;22(4):412-421. doi: 10.4103/aca.ACA_116_18.

Preconditioning in cardiac anesthesia…… where are we?

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Department of CVTS, MCRI MGM Medical College and Hospital, Aurangabad, Maharashtra, India.


Preconditioning, a milestone concept in the cardiovascular sciences introduced 32 years back by Murry. This concept opened a new era in the field of organ protection. To start with extensive studies done on ischemic preconditioning for myocardial protection, ischemic preconditioning is an endogenous science of cellular kinetics. Several components in signal transduction cascade have been identified but still some mechanisms not yet revealed. Anesthetic preconditioning also contributed a lot for myocardial protection and concreted the concept of preconditioning. We, with an inquisitive brain meticulously persuing newer methods of cardioprotection. Remote ischemic preconditioning (RIPC) is a brilliant example of it. RIPC can be future of cardioprotection, clinical trials and studies proved the benefits but yet to conclude the superiority of RIPC over myocardial ischemic cardioprotection. This review is an attempt to reveal this extraordinary concept with its basic cellular kinetics, methods, and recent trends.


Anesthetic preconditioning; ischemic preconditioning; myocardial protection; remote ischemic preconditioning

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