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Middle East Afr J Ophthalmol. 2019 Sep 30;26(3):168-171. doi: 10.4103/meajo.MEAJO_97_19. eCollection 2019 Jul-Sep.

Use of Fibrin Glue in the Management of Descemet Membrane Perforation during Deep Anterior Lamellar Keratoplasty.

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Department of Ophthalmology, Anterior Segment Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.
Division of Ophthalmology, Department of Surgery, King Abdullah bin Abdulaziz University Hospital, Riyadh, Saudi Arabia.



To describe the use of fibrin glue to seal Descemet membrane (DM) microperforation and macroperforation during deep anterior lamellar keratoplasty (DALK).


A retrospective chart review was performed on patients who had DM perforation managed by fibrin glue during DALK at King Khaled Eye Specialist Hospital (KKESH) between June 2014 and February 2019.


One thousand two hundred and eighty-eight DALK surgeries were performed at KKESH during the study period. Fibrin glue was used to seal DM perforations in four cases of DALK for keratoconus.


Fibrin glue is an effective method to seal DM microperforations and macroperforations during DALK, which reduces the rate of conversion to penetrating keratoplasty (PK), preserving the advantage of DALK over PK.


Deep anterior lamellar keratoplasty; Descemet membrane; fibrin glue

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