Format

Send to

Choose Destination
Nutrients. 2019 Oct 15;11(10). pii: E2466. doi: 10.3390/nu11102466.

Prevalence of Medication-Dietary Supplement Combined Use and Associated Factors.

Author information

1
Teaching, Research & Innovation Unit, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Parc Sanitari Sant Joan de Déu, 08830 Sant Boi de Llobregat (Barcelona), Spain. i.aznar@pssjd.org.
2
Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública, CIBERESP, 28029 Madrid, Spain. i.aznar@pssjd.org.
3
Teaching, Research & Innovation Unit, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Parc Sanitari Sant Joan de Déu, 08830 Sant Boi de Llobregat (Barcelona), Spain. c.carbonell@pssjd.org.
4
Spanish Society of Community and Family Pharmacy (SEFAC), 28045 Madrid, Spain. ana.rodriguez@sefac.org.
5
Spanish Society of Community and Family Pharmacy (SEFAC), 28045 Madrid, Spain. ines.mera@hotmail.es.
6
Teaching, Research & Innovation Unit, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Parc Sanitari Sant Joan de Déu, 08830 Sant Boi de Llobregat (Barcelona), Spain. mrubio@pssjd.org.
7
Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública, CIBERESP, 28029 Madrid, Spain. mrubio@pssjd.org.
8
School of Pharmacy, University of Barcelona, 08028 Barcelona, Spain. mrubio@pssjd.org.

Abstract

INTRODUCTION:

The use of medication has increased in recent years in the US while the use of dietary supplements has remained stable but high. Interactions between these two kinds of products may have important consequences, especially in the case of widely used medications such as antihypertensives and antibiotics. The aim of this paper is to estimate the prevalence of potentially serious drug-dietary supplement interactions among tetracyclines, thiazides, and angiotensin II receptor blocker users by means of the NHANES 2013-2014 dataset.

METHODS:

Data from 2013-2014 NHANES were obtained. Potential interactions analysed were tetracyclines with calcium, magnesium, and zinc, thiazides with vitamin D, and angiotensin II receptors blockers with potassium. Prevalence was calculated for each potential interaction. Logistic regression was used to assess associated factors.

RESULTS:

864 prescriptions issued to 820 patients were analysed. Overall prevalence of potential interaction was 49%. Older age and higher educational level were strongly associated with being at risk of a potential interaction. Factors such as age, race, civil status, citizenship, country of birth, BMI, and physical activity did not show notable associations.

CONCLUSIONS:

Healthcare professionals should be aware of other medical products when they prescribe or dispense a medication or a dietary supplement, especially to the older population and people with a higher educational level.

KEYWORDS:

antibiotics; antihypertensive medication; dietary supplements; interactions; prevalence

PMID:
31618867
PMCID:
PMC6835757
DOI:
10.3390/nu11102466
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center